David B. Thomas

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Epidemiology
Member
University of Washington
School of Public Health and Community Medicine
Epidemiology
Professor
Professional Headshot of David B. Thomas

Mailing Address

Fred Hutchinson Cancer Research Center
Program in Epidemiology
M4-B874
1100 Fairview Avenue North
PO Box 19024
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-5133
Fax: (206) 667-4787
dbthomas@fhcrc.org

Degrees

Dr.P.H., Johns Hopkins University, 1972.
M.D., University of Washington, 1963.

Research Interests

My expertise is in the following areas:
cancer epidemiology
breast cancer epidemiology
cervical cancer epidemiology
tobacco-related cancer
steroid contraceptives
cancer screening
 

Additional Experience

From 1978 to 1992, Dr. Thomas coordinated for the World Health Organization (WHO) a collaborative study in 11 countries on five continents. The purposes of this study were to assess the effects of steroid contraceptives and other factors on risks of cancers of the breast, cervix, ovary, endometrium, and liver. The WHO study showed that women are at increased risk of cervical cancer if, prior to marriage, their husbands frequently visited prostitutes and did not use condoms during those visits. Certain strains of human papillomaviruses (HPV) are the sexually transmitted agents that are probably necessary causes of cervical cancer, and Dr. Thomas conducted a subsequent study in Bangkok that confirmed the role of prostitutes as a reservoir of oncogenic HPV strains, and of their customers as vectors for transmission of these viruses to women in the general population. That study also provided evidence that persistence of oncogenic types of HPV, which leads to carcinogenesis, is associated with endgenous and exgenous hormonal factors and smoking, as well as immunosuppression. With the possible exception of Vitamin A, which may inhibit progression from in situ to invasive disease, other co-factors appeared to act earlier in the carcinogenic process.

In 1988, Dr. Thomas initiated a randomized trial of breast self-examination (BSE) in Shanghai, China. More than 267,000 women in 519 textile factories were interviewed to obtain information on risk factors for breast cancer, and randomly assigned by factory to a BSE instruction group or control group. Women in both groups were monitored for the development of benign and malignant breast tumors, and for mortality through 2000. Mortality from breast cancer was the same in the instruction and control groups, providing strong evidence that teaching BSE does not reduce deaths from breast cancer. This study population also serves as a resource for independently funded investigations conducted in collaboration with other investigators at the Center. One such study showed that induced abortions did not alter the incidence rate of breast cancer. Other investigations have included studies of: the determinants of cell proliferation in benign and malignant tumor tissue and in normal tissue adjacent to tumors; the role of nutritional factors in the etiology of benign and malignant breast diseases; the role of breast cancer genes BRCA-1 and BRCA-2 in the development of breast cancer; the possible role in the etiology of breast cancer of polymorphisms in multiple genes involved in hormone biosynsthesis and catabolism, and of genes for certain growth factors and hormone receptors; and the possible etiologic role of electromagnetic field exposure in the etiology of breast cancer. In addition, risks of other types of cancer in relation to contraceptive methods and occupational exposures have been assessed in women in the trial cohort.

Dr. Thomas also conducted a study in Seattle that showed that radiographic densities and certain types of calcifications on mammograms in women under 50 can be used to identify women at increased risk of subsequent breast cancer.

Dr. Thomas is former Head of both the Epidemiology and Breast Cancer Programs at the Fred Hutchinson Cancer Research Center, and former Director of the Cancer Surveillance System of Western Washington which is a population-based cancer registry.

Future Research

Plans are underway with colleagues to utilize the resources from the studies in Shanghai to conduct additional investigations into the etiology and natural history of breast and other cancers. Studies under consideration include: use of microarray technology to identify determinants of breast cancer development in benign breast tissue and of survival in malignant breast tissue; development and testing of biologically based mathematical models to investigate mammary carcinogenesis.

Memberships

American Association for the Advancement of Science
American College of Epidemiology
American Epidemiological Society
American Society of Preventive Oncology
International Association of Cancer Registries
Physicians for Social Responsibility
Society for Epidemiologic Research

Honors and Awards

1999, Honorary Member, International Association of Cancer Registries
1996, Johns Hopkins University Society of Scholars,
1994, Fellow, American Association For the Advancement of Science
1990, Fellow, American College of Epidemiology

Previous Positions

1994-2000, Program Head, Fred Hutchinson Cancer Research Center, Program in Epidemiology, Public Health Division
1994-1998, Head, Fred Hutchinson Cancer Research Center, Seattle Breast Cancer Research Program
1983-2000, Director, Cancer Surveillance System of Western Washington

Funding

  • National Cancer Institute: Randomized Trial of Breast Self-Examination in Shanghai, May 18, 1988 to Mar 31, 2003.
  • National Cancer Institute: Diet, Cell Proliferation, and the Risk of Breast Cancer in Shanghai, Jul 1, 1997 to Jun 30, 2003.
  • National Institutes of Health (NIH): Contraceptive Use and Risk of Cancer in Shanghai, 1998 to 2000.
  • National Institutes of Health (NIH): Predictive Value of Mammograms in Women Under Age 50, 1995 to 1997.
  • National Institutes of Health (NIH): Seattle Breast Cancer Research Program, 1994 to 2000.
  • National Institutes of Health (NIH): Papilloma Viruses and Cervical Cancer in Bangkok, 1990 to 1994.
  • National Institutes of Health (NIH): Epidemiology of Male Breast Cancer, 1983 to 1987.
  • World Health Organization: WHO Collaborative Study of Neoplasia and Steroid Contraceptives, 1979 to 1992.

 

Recent Publications

2014
2013
2012
2011
2010
2009
2008