Brian Till

Appointments and Affiliations

Fred Hutchinson Cancer Research Center
Clinical Research Division
Assistant Member, Appointed: 2012
 
University of Washington
Medicine
Assistant Professor, Appointed: 2012
 
Seattle Cancer Care Alliance
Stem Cell Transplant Service
Attending Physician
Professional Headshot of Brian Till

Mailing Address

Fred Hutchinson Cancer Research Center
D3-100
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-7269
Fax: (206) 667-1874
tillb@fhcrc.org

Degrees

M.D., Pritzker School of Medicine, University of Chicago, 2002.
B.S., Biology, The Catholic University of America, 1998.

Research Interests

Dr. Till is developing novel lymphoma immunotherapies, based on adoptive T cell transfer.
  1. The primary project of the laboratory is development of a CD20-targeted chimeric antigen receptor (CAR) for use in human clinical trials for patients with CD20-expressing B cell malignancies. In addition to generation of a clinical-grade lentiviral vector expressing this construct and optimization of culture conditions, the lab is performing correlative experiments using specimens from patients treated with CAR T cell products to assess the in vivo expansion, persistence and functionality of adoptively transferred T cells.
  2. Other ongoing explorations are focused on costimulation in CAR T cells, particularly evaluating the extent to which costimulatory domains encoded as part of the CAR construct are sufficient to replace endogenous costimulatory signals.
  3. Ways to enhance in vivo function of CAR T cells through blockade or knockdown of checkpoint molecules are being pursued, focusing on expression of a secreted anti-CTLA4 construct designed to be expressed by CAR T cells in the tumor microenvironment, thus limiting systemic autoimmune toxicities.
  4. An immunocompetent model is being used to study the effects of CAR T cells on the endogenous immune system, particularly whether CAR T cell mediated tumor destruction can elicit adaptive immune responses and epitope spreading, and whether this process can be enhanced with the use of other immune adjuvant agents, either administered systemically or secreted by the T cells.

Previous Positions

2011-2012: Associate in Clinical Research, Fred Hutchinson Cancer Research Center.
2008-2011: Research Associate, Fred Hutchinson Cancer Research Center.
2008-2012: Acting Instructor, University of Washington.

Additional Experience

2005-2008: Fellowship, Oncology, Fred Hutchinson Cancer Research Center.
2003-2005: Residency, Internal Medicine, Hospital of the University of Pennsylvania.
2002-2003: Internship, Internal Medicine, Hospital of the University of Pennsylvania.

Memberships

2006-present, Member, American Society of Hematology
2009-present, Member of Working Group on Lymphoma Committee, SWOG (formerly Southwest Oncology Group)
2007-2009, Member, American Society of Clinical Oncology
2007-2008, Associate Member, American Association for Cancer Research

Honors and Awards

2012: NCI Cancer Center Support Grant recruitment award (from UW/FHCRC Cancer Consortium)
2011: Moderator, Oral Abstract Session at American Society of Hematology annual meeting
2010: Damon Runyon Clinical Investigator Award
2009: Southwest Oncology Group (SWOG) Young Investigator
2009: NIH Loan Repayment Program recipient
2008: Featured as distinguished alumnus in CUA Annual Report
2008: Lymphoma Research Foundation Clinical Investigator Career Development Grant
2008: ASCO Cancer Foundation Young Investigator Award (YIA). Research proposal was sponsored by the Journal of Clinical Oncology (one award per year achieves this distinction).
2007: American Society of Hematology Travel Award.
2007: ASCO/AACR Workshop on Methods in Clinical Cancer Research Participant.
2007: University of Washington General Clinical Research Center Pilot and Feasibility Grant.
1999: NIH Student Summer Research Award, University of Chicago.
1998: Summa Cum Laude, CUA.
1998: CUA Academic Excellence Award in Biology.
1997: Roy Bode Memorial Award for student leadership, CUA.
1997: Thomas Jefferson University Summer Research Program Award.
1996: NSF Institute for Biological Timing Summer Research Award (University of Virginia).
1996: H.P. Ward Prize for Excellence in Organic Chemistry, CUA.
Howard Hughes Medical Institute Summer Research Award (CUA).
1995: F.O. Rice Award for Excellence in Freshman Chemistry, CUA.
1995: CRC Press Freshman Chemistry Achievement Award, CUA
1993-1998: Archdiocesan Scholarship (full tuition), The Catholic University of America (CUA).

Board Certification and Eligibility

Medical Oncology (ABIM), 10/2008 - 12/2018
Internal Medicine (ABIM), 08/2005 - 12/2015

Current License(s) to Practice

Washington State License, 02/2005 - 08/21/2013

Funding

  • Clinical Investigator Award, Damon Runyon Cancer Research Foundation: Optimization of adoptive immunotherapy for lymphoma using genetically modified CD20-specific T cells, Principal Investigator, 7/1/2010 – 6/30/2013.
  • NIH/NCI Cancer Center Support Grant (PI: Corey), 1/1/1977 – 12/31/2014.
    Sub-Project: CCSG Recruitment Award, Principal Investigator, 7/1/2012 - 6/30/2015.

Recent Publications

2015
2014
2013
2012
2011
2010
2009
2008