Ph.D., Texas A&M University-College Station, Statistics, 1993.
M.S., National Tsing-Hua University, Applied Mathematics, 1985.
Missing Data, Measurement Error and Nutritional Epidemiology.
I have two primary biostatistics research activities: (1) methodology research on missing data, measurement error models, longitudinal data and survival analysis; (2) application of methods to epidemiological data.
Missing data and measurement error are very practical and interesting problems. Due to certain reasons, such as high cost, some data can only be collected for a small subsample. For example, food frequency questionnaires are commonly used to assess dietary intake for most study participants, while other instruments such as 4DFR may be subsequently administered only to a subsample of participants to reduce costs. Other factors of missing data problem may be due to the design eligibility criteria. The Women's Health Initiative's dietary intervention trial is a standard example. Furthermore, nutrients are often measured with error. Ignorance of the measurement error may sometimes dead to considerable bias to the study results.
Dietary intervention trialshave been strategies for the nutritional prevention of cancer. This leads to a covariate measurement error problem in regression models. A closely related problem arising from the regression analysis of two-stage case-control studies. To this problem, I have developed some parametric, semiparametric and nonparametric methods.
I am also interested in the missing data and measurement error problem in censored failure time data. Some work has been done in this field.
Recently, I have been working on regression analysis when the disease outcome is related to longitudinal data which are observations from a random effects model. This problem is often called joint modeling or two-stage modeling. The primary regression is to relate disease outcome to some latent covariates, while the auxillary data regression is to model covariate data.
I am also interested in the missing data and measurement error problem in censored failure time data.
(Reading, Writing, Speaking)
Chinese, Mandarin: (Fluent, None, None)
English: (Fluent, None, None)
American Statistical Association
Honors and Awards
The H.O. Hartley Award, Department of Statistics, Texas A&M University
2001-2005, Affiliate Associate Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1998-2002, Associate Member, Fred Hutchinson Cancer Research Center, Biostatistics, Public Health Sciences
1993-1998, Assistant Member, Fred Hutchinson Cancer Research Center, Biostatistics, Public Health Sciences
1993-2001, Affiliate Assistant Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1989-1993, Teaching/Research Assistant, Texas A&M University-College Station, Statistics
1987-1989, Research Assistant, Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
Effect of a 12-month Exercise Intervention on Serum Biomarkers of Angiogenesis in Postmenopausal Women: a randomized controlled trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2014.
Sedentary Behavior and Mortality in Older Women: The Women's Health Initiative.. American journal of preventive medicine. 46(2):122-35.. 2014.
Comparison and validation of 2 analytical methods for measurement of urinary sucrose and fructose excretion.. Nutrition research (New York, N.Y.). 33(9):696-703.. 2013.
Predicting Adherence of Adults to a 12-Month Exercise Intervention.. Journal of physical activity & health.. 2013.
Time-varying coefficient proportional hazards model with missing covariates.. Statistics in medicine. 32(12):2013-30.. 2013.
Long-Term Physical Activity Trends in Breast Cancer Survivors.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2013.
Predictors of Adherence to a 26-Week Viniyoga Intervention Among Post-Treatment Breast Cancer Survivors.. Journal of alternative and complementary medicine (New York, N.Y.).. 2013.
An automated intervention with stepped increases in support to increase uptake of colorectal cancer screening: a randomized trial.. Annals of internal medicine. 158(5 Pt 1):301-11.. 2013.
Gene Expression Changes in Adipose Tissue with Diet- and/or Exercise-Induced Weight Loss.. Cancer prevention research (Philadelphia, Pa.). 6(3):217-31.. 2013.
Weight, inflammation, cancer-related symptoms and health-related quality of life among breast cancer survivors.. Breast cancer research and treatment.. 2013.
Exercise adherence, cardiopulmonary fitness and anthropometric changes improve exercise self-efficacy and health-related quality of life.. Journal of physical activity & health. 10(5):676-89.. 2013.
Effects of dietary weight loss and exercise on insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in postmenopausal women: a randomized controlled trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(8):1457-63.. 2013.
Exercise Adherence, Cardiopulmonary Fitness and Anthropometric Changes Improve Exercise Self-Efficacy and Health-Related Quality of Life.. Journal of physical activity & health.. 2012.
Influence of Diet, Exercise, and Serum Vitamin D on Sarcopenia in Postmenopausal Women.. Medicine and science in sports and exercise.. 2012.
Expected estimating equations via EM for proportional hazards regression with covariate misclassification.. Biostatistics (Oxford, England).. 2012.
Sexual risk behaviors, circumcision status and pre-existing immunity to adenovirus type 5 among men who have sex with men participating in a randomized HIV-1 vaccine efficacy trial: Step Study.. Journal of acquired immune deficiency syndromes (1999).. 2012.
Associations of insulin-like growth factor and insulin-like growth factor binding protein-3 with mortality in women with breast cancer.. International journal of cancer. Journal international du cancer.. 2012.
Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30(19):2314-26.. 2012.
A low-glycemic load diet reduces serum C-reactive protein and modestly increases adiponectin in overweight and obese adults.. The Journal of nutrition. 142(2):369-74.. 2012.
History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women.. Metabolism: clinical and experimental.. 2012.
Effect of diet and exercise, alone or combined, on weight and body composition in overweight-to-obese postmenopausal women.. Obesity (Silver Spring, Md.). 20(8):1628-38.. 2012.