Ph.D., University of Washington, Biostatistics, 2002.
M.S., University of Washington, Biostatistics, 1999.
M.A., Washington University in St. Louis, Psychology, 1997.
B.S., Peking University, Psychology, 1992.
My research interests have been in the statistical methods for longitudinal data with time-to-event outcome, with a focus on using semi-parametric methods for estimating time-dependent ROC curves which are useful for evaluating the ability of longitudinal biomarkers or algorithms to identify cancer early, or signal disease prognosis. I am also interested in statistical methods for family-based genetic association studies. I am presently providing support to a number of research proposals and applications in the cancer prevention research program, including serving as an investigator in the DMCC of the Early Detection Research Network.
(Reading, Writing, Speaking)
Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)
Honors and Awards
2006, Best Paper in Biometrics during 2004-2005, award selection by journal editors, International Biometeric Society
2003, Senior Biostatistics Student Award, University of Washington
1996, Division 20 'Completed Research Competition' Award, American Psychological Association
1994-1995, Merit Based Graduate Fellowship, Washington University
1989-1990, GuangHua Award for Academic Excellence, Peking University
2002-2008, Affiliate Assistant Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
2002-2007, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Cancer Prevention Research Program
2000-2002, Dissertation Research, University of Washington, School of Public Health and Community Medicine, Biostatistics
1997-2002, Research Assistant, Group Health Cooperative, Center for Health Studies
1996-1997, Teaching Assistant, University of Washington, College of Arts and Sciences, Psychology
1995-1997, Research Assistant, University of Washington, Aging and Develpment Program, Psychology
A unified mixed-effects model for rare-variant association in sequencing studies.. Genetic epidemiology. 37(4):334-44.. 2013.
The Early Detection Research Network's Specimen Reference Sets: Paving the Way for Rapid Evaluation of Potential Biomarkers.. Clinical chemistry. 59(1):68-74.. 2013.
B vitamin intakes and incidence of colorectal cancer: results from the Women's Health Initiative Observational Study cohort.. The American journal of clinical nutrition. 97(2):332-43.. 2013.
Homocysteine, cysteine, and risk of incident colorectal cancer in the Women's Health Initiative observational cohort.. The American journal of clinical nutrition. 97(4):827-34.. 2013.
Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers.. International journal of cancer. Journal international du cancer.. 2012.
Evaluating Prognostic Accuracy of Biomarkers under Competing Risk.. Biometrics. 68(2):388-396.. 2012.
Evaluating prognostic accuracy of biomarkers in nested case-control studies.. Biostatistics (Oxford, England). 13(1):89-100.. 2012.
Subgroup specific incremental value of new markers for risk prediction.. Lifetime data analysis.. 2012.
Evaluating the predictive value of biomarkers with stratified case-cohort design.. Biometrics. 68(4):1219-27.. 2012.
Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers.. Molecular & cellular proteomics : MCP. 10(10):M111.008599.. 2011.
Pre-diagnostic NSAID use but not hormone therapy is associated with improved colorectal cancer survival in women.. British journal of cancer. 104(5):763-8.. 2011.
Robust prediction of t-year survival with data from multiple studies.. Biometrics. 67(2):436-44.. 2011.
The association between worksite social support, diet, physical activity and body mass index.. Preventive medicine. 53(1-2):53-6.. 2011.
Exploring the role of co-worker social support on health care utilization and sickness absence.. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. 53(7):751-7.. 2011.
Determinants of aspirin metabolism in healthy men and women: effects of dietary inducers of UDP-glucuronosyltransferases.. Journal of nutrigenetics and nutrigenomics. 4(2):110-8.. 2011.
Nidogen-2: a new serum biomarker for ovarian cancer.. Clinical biochemistry. 43(4-5):355-61.. 2010.
Semiparametric models of time-dependent predictive values of prognostic biomarkers.. Biometrics. 66(1):50-60.. 2010.
On combining family-based and population-based case-control data in association studies.. Biometrics. 66(4):1024-33.. 2010.
Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 20(4):305-9.. 2010.
Use of folic acid-containing supplements after a diagnosis of colorectal cancer in the Colon Cancer Family Registry.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 19(8):2023-34.. 2010.
A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus.. Cancer research. 69(10):4112-5.. 2009.
The association of tumor microsatellite instability phenotype with family history of colorectal cancer.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(3):967-75.. 2009.
Activated leukocyte cell adhesion molecule: a novel biomarker for breast cancer.. International journal of cancer. Journal international du cancer. 125(1):9-14.. 2009.