Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.

Publication Type:

Journal Article

Authors:

Reding, Kerryn W; Weiss, Noel S; Chen, Chu; Li, Christopher I; Carlson, Christopher S; Wilkerson, Hui-Wen; Farin, Federico M; Thummel, Kenneth E; Daling, Janet R; Malone, Kathleen E

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 18, Issue 5, p.1461-7 (2009)

Keywords:

2009, Aged, Alleles, Aryl Hydrocarbon Hydroxylases, Breast Neoplasms, Case-Control Studies, Catechol O-Methyltransferase, Center-Authored Paper, Epidemiology Core Facility, Estrogens, Catechol, Female, Genetic Predisposition to Disease, Glutathione S-Transferase pi, Glutathione Transferase, Haplotypes, Humans, Polymorphism, Single Nucleotide, Postmenopause, Public Health Sciences Division, RISK, SEER Program, Shared Resources, Specimen Processing Core Facility, Washington

Abstract:

This study investigated whether single nucleotide polymorphisms (SNP) in genes within the catechol estrogen metabolism pathway altered the risk of breast cancer alone or in combination, as well as whether menopausal hormone therapy modified the effect of these SNPs on breast cancer risk.