Long-term use of acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs and risk of hematologic malignancies: results from the prospective Vitamins and Lifestyle (VITAL) study.

Publication Type:

Journal Article

Authors:

Walter, Roland B; Milano, Filippo; Brasky, Theodore M; White, Emily

Source:

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 29, Issue 17, p.2424-31 (2011)

Keywords:

2011, Acetaminophen, Aged, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Clinical Research Division, Cohort Studies, Female, Hematologic Neoplasms, Humans, Life Style, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Public Health Sciences Division, RISK, Sex Characteristics

Abstract:

Among previous studies examining the associations of over-the-counter analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs) and incident hematologic malignancies, results were inconsistent for NSAIDs but suggested an increased risk with acetaminophen (paracetamol). Herein, we used a large prospective cohort study to examine these associations.